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核心技术专利：CN118964589B侵权必究

核心技术专利：CN118964589B侵权必究

Alsharif M, Apweiler R, Whish W J, Branford White C J, Brunt R V

Department of Biochemistry, University of Bath, UK.

Comp Biochem Physiol B. 1990;96(3):527-31. doi: 10.1016/0305-0491(90)90051-t.

The nuclear fraction of the rat tapeworm Hymenolepis diminuta (Cestoda) contains the enzyme adenosine diphosphoribosyl transferase (ADPR-transferase). 2. The enzyme catalyzes the postsynthetic modification of some nuclear proteins by the covalent attachment of the (ADP-ribose) moiety of NAD to such proteins. 3. The reaction is dependent on DNA which contains strand-breaks, and chain lengths equivalent to (ADP-ribose) is estimated. 4. The formation of polynucleotide products was competitively inhibited by 3-acetamidobezamide, with a Km of 125 microM. 5. The catalytic properties of ADPR-transferase in Hymenolepis diminuta are similar to those in T. brucei.

Alsharif M, Apweiler R, Whish W J, Branford White C J, Brunt R V

Department of Biochemistry, University of Bath, UK.

Comp Biochem Physiol B. 1990;96(3):527-31. doi: 10.1016/0305-0491(90)90051-t.

The nuclear fraction of the rat tapeworm Hymenolepis diminuta (Cestoda) contains the enzyme adenosine diphosphoribosyl transferase (ADPR-transferase). 2. The enzyme catalyzes the postsynthetic modification of some nuclear proteins by the covalent attachment of the (ADP-ribose) moiety of NAD to such proteins. 3. The reaction is dependent on DNA which contains strand-breaks, and chain lengths equivalent to (ADP-ribose) is estimated. 4. The formation of polynucleotide products was competitively inhibited by 3-acetamidobezamide, with a Km of 125 microM. 5. The catalytic properties of ADPR-transferase in Hymenolepis diminuta are similar to those in T. brucei.