Ioniţă-Radu Florentina, Bucurică Săndica, Costache Raluca, Nuţă P, Stanciu S
"Carol Davila" Central Clinical Military Hospital, Bucharest, Romania.
Rom J Intern Med. 2010;48(1):105-8.
We present the case of young women who developed celiac disease during the treatment for chronic hepatitis C. Celiac disease is now considered to be an immune disorder that is triggered by an environmental agent in genetically predisposed persons. Many studies have shown that the total prevalence of gluten sensitive-enteropathy has increased over last decades, and advances in serological screening leads to the idea that there are more celiac disease cases that are asymptomatic and undiagnosed. Actually, pegylated interferonum (IFN) in combination with ribavirine provides the most effective treatment for patient with chronic hepatitis C. However, interferon and ribavirin therapy are associated with induction or exacerbation of preexistent autoimmune disorders.
我们报告了一名年轻女性在慢性丙型肝炎治疗期间患上乳糜泻的病例。乳糜泻现在被认为是一种免疫紊乱疾病，由环境因素在具有遗传易感性的个体中引发。许多研究表明，过去几十年来，麸质敏感性肠病的总体患病率有所上升，血清学筛查的进展使人们认为有更多无症状和未被诊断的乳糜泻病例。实际上，聚乙二醇化干扰素（IFN）联合利巴韦林为慢性丙型肝炎患者提供了最有效的治疗方法。然而，干扰素和利巴韦林治疗与既往存在的自身免疫性疾病的诱发或加重有关。
