Kavgaci H, Yildiz B, Fidan E, Reis A, Ozdemir F, Cobanoglu U, Can G
Department of Medical Oncology, Faculty of Medicine, Karadeniz Technical University, Trabzon, Turkey.
Bratisl Lek Listy. 2010;111(9):493-7.
Breast cancer is the most common malignancy in women. Axillary lymph node involvement and tumor size are the most significant prognostic factors in breast cancer. However, more factors are needed for evaluating the prognosis and individualizing the treatment in these patients. Intracellular adhesion molecule E-cadherin, antiapopitotic protein bcl-2, and p53 might have predictive and prognostic properties in breast cancer.
We have investigated the effects of E-cadherin, bcl-2, and p53 on disease free survival and overall survival in patients with breast cancer.
Positivity of aforementioned genes was detected with immunohistochemistry staining. Seventy-six women patients with invasive ductal and lobular breast cancer who had received adjuvant therapy were included in the study.
Bcl-2, E-cadherin, and p53 expression in tumor tissue specimens were found in 26.31%, 35.52%, and 9.21%, respectively. Mean duration of follow-up was 93.58 +/- 3.40 months. In multivariate analyses, axillary lymph node presence and C-erb-B2 overexpression were a strong negative prognostic factor of disease free survival and overall survival. E-cadherin and bcl-2 failed to have an effect on disease free survival and overall survival in our study. In addition, p53 overexpression was determined in a limited number of patients.
The results of this study showed that E-cadherin, bcl-2, and p53 did not have any significant prognostic value for our patients. In order to arrive at a decision, we need studies, which include more patients and long follow-up periods (Tab. 2, Fig. 2, Ref. 24).
乳腺癌是女性最常见的恶性肿瘤。腋窝淋巴结受累情况和肿瘤大小是乳腺癌最重要的预后因素。然而，评估这些患者的预后并实现治疗个体化还需要更多因素。细胞内粘附分子E-钙粘蛋白、抗凋亡蛋白bcl-2和p53可能在乳腺癌中具有预测和预后特性。
我们研究了E-钙粘蛋白、bcl-2和p53对乳腺癌患者无病生存期和总生存期的影响。
采用免疫组织化学染色检测上述基因的阳性情况。本研究纳入了76例接受辅助治疗的浸润性导管癌和小叶癌女性患者。
肿瘤组织标本中bcl-2、E-钙粘蛋白和p53的表达率分别为26.31%、35.52%和9.21%。平均随访时间为93.58±3.40个月。多因素分析显示，腋窝淋巴结转移和C-erb-B2过表达是无病生存期和总生存期的强阴性预后因素。在我们的研究中，E-钙粘蛋白和bcl-2对无病生存期和总生存期没有影响。此外，仅在少数患者中检测到p53过表达。
本研究结果表明，E-钙粘蛋白、bcl-2和p53对我们的患者没有显著的预后价值。为了做出决策，我们需要开展纳入更多患者且随访期更长的研究（表2，图2，参考文献24）。
