异基因骨髓移植治疗白血病。
Allogeneic bone marrow transplantation for the treatment of leukemia.
作者信息
Lu D P, Guo N L, Jin N R, Zheng H, Lu X J, Shi Q, Shan F X, Jiang B, Tang H, Liu M Y
机构信息
Institute of Hematology and People's Hospital, Beijing Medical University, China.
出版信息
Chin Med J (Engl). 1990 Feb;103(2):125-30.
Eighteen patients with leukemia have received HLA-identical allogeneic bone marrow transplantation (BMT) at our hospital since 1981. Fifteen of these patients have been living without relapse. for prophylaxis of GVHD, MTX was used in 8 patients, and cyclosporine (CSP) together with MTX in 6 patients, 3 received multiple agents at much smaller dosage, including monoclonal antibody. All patients received intravenous placental gamma-globulin, and 16 received garlic extract. Three patients died. One, who neither received MTX, nor CSP died of hyperacute GVHD, one who did not receive garlic extract died of GMV pneumonia, and the third one died of tuberculosis 18 months after BMT.
自1981年以来，我院有18例白血病患者接受了 HLA 配型相合的异基因骨髓移植（BMT）。其中15例患者目前无疾病复发存活。为预防移植物抗宿主病（GVHD），8例患者使用了甲氨蝶呤（MTX），6例患者使用环孢素（CSP）联合MTX，3例患者使用了包括单克隆抗体在内的多种小剂量药物。所有患者均接受了静脉注射胎盘丙种球蛋白，16例患者接受了大蒜提取物治疗。3例患者死亡。1例既未接受MTX也未接受CSP的患者死于超急性GVHD，1例未接受大蒜提取物的患者死于巨细胞病毒（GMV）肺炎，第3例患者在BMT后18个月死于肺结核。
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