吉格里纳的神经药理学安全性评价：一种多草药肝脏保护制剂。
Neuropharmacological safety evaluation of jigrine: A polyherbal hepatoprotective formulation.
作者信息
Najmi A K, Pillai K K, Pal S N, Akhtar M, Mujeeb M, Aftab A
机构信息
Department of Pharmacology, India.
出版信息
J Pharm Bioallied Sci. 2010 Oct;2(4):329-32. doi: 10.4103/0975-7406.72134.
Abstract
OBJECTIVE
Jigrine is a herbal hepatoprotective formulation containing aqueous extracts of 14 medicinal plants. Present study was designed to evaluate per se neuropharmacological effects of jigrine in mice.
MATERIALS AND METHODS
Jigrine was evaluated in a number of pharmacological test paradigms, viz. open field arena, actophotometer, hole board, rotarod, traction test, grip strength test, spontaneous alternation behavior, passive avoidance task, and phenobarbital sleeping time.
RESULTS AND CONCLUSIONS
Jigrine pretreatment (1 and 2 ml/kg, p.o.) did not produce any significant effect as compared to normal saline treated animals and was found to be free from any acute undesirable central effects at these two dose levels.
摘要
目的
吉格林是一种含有14种药用植物水提取物的草药保肝制剂。本研究旨在评估吉格林对小鼠本身的神经药理学作用。
材料与方法
在多种药理学测试范式中对吉格林进行了评估，即旷场实验、光电计实验、洞板实验、转棒实验、牵引实验、握力实验、自发交替行为实验、被动回避任务实验和苯巴比妥睡眠时间实验。
结果与结论
与生理盐水处理的动物相比，吉格林预处理（1和2毫升/千克，口服）未产生任何显著影响，并且发现在这两个剂量水平下没有任何急性不良中枢效应。
相似文献
1
Neuropharmacological safety evaluation of jigrine: A polyherbal hepatoprotective formulation.吉格里纳的神经药理学安全性评价：一种多草药肝脏保护制剂。
J Pharm Bioallied Sci. 2010 Oct;2(4):329-32. doi: 10.4103/0975-7406.72134.
2
Free radical scavenging and hepatoprotective activity of jigrine against galactosamine induced hepatopathy in rats.
J Ethnopharmacol. 2005 Mar 21;97(3):521-5. doi: 10.1016/j.jep.2004.12.016.
3
Evaluation of hepatoprotective potential of jigrine post-treatment against thioacetamide induced hepatic damage.对叶百部治疗后对硫代乙酰胺诱导的肝损伤的肝保护潜力评估。
J Ethnopharmacol. 2002 Jan;79(1):35-41. doi: 10.1016/s0378-8741(01)00349-x.
4
Hepatoprotective and behavioral effects of jigrine in galactosamine-induced hepatopathy in rats.水飞蓟宾对半乳糖胺诱导的大鼠肝损伤的肝保护作用和行为学影响。
Pharm Biol. 2010 Jul;48(7):764-9. doi: 10.3109/13880200903300188.
5
Investigations of anti-inflammatory activity of Jigrine.虎眼万年青抗炎活性的研究。
Indian J Physiol Pharmacol. 1997 Apr;41(2):134-8.
6
Development and evaluation of hepatoprotective polyherbal formulation containing some indigenous medicinal plants.含某些本土药用植物的保肝多草药配方的研发与评价
Indian J Pharm Sci. 2008 Mar-Apr;70(2):265-8. doi: 10.4103/0250-474X.41474.
7
Hepatoprotective Effect of A Polyherbal Extract Containing Andrographis Paniculata, Tinospora Cordifolia and Solanum Nigrum Against Paracetamol Induced Hepatotoxicity.一种含有穿心莲、心叶青牛胆和龙葵的多草药提取物对扑热息痛诱导的肝毒性的肝保护作用。
Pharmacogn Mag. 2015 Oct;11(Suppl 3):S375-9. doi: 10.4103/0973-1296.168945.
8
Hepatoprotective activity of six polyherbal formulations in paracetamol induced liver toxicity in mice.六种复方草药制剂对扑热息痛诱导的小鼠肝毒性的保肝活性。
Indian J Med Res. 2009 May;129(5):569-78.
9
Safety evaluation and therapeutic efficacy of Habb-e-Asgand, a commonly used antirheumatic polyherbal Unani formulation.常用抗风湿复方尤纳尼制剂哈布-阿斯甘德的安全性评价与治疗效果
Altern Ther Health Med. 2013 Sep-Oct;19(5):52-9.
10
Clinical efficacy and safety of a pharmacopial polyherbal Unani formulation in pityriasis versicolor: a comparative randomized single-blind study.临床疗效和安全性的一种药剂复方制剂的 Unani pityriasis 花斑癣: 一个比较随机单盲研究。
J Altern Complement Med. 2012 Oct;18(10):978-82. doi: 10.1089/acm.2011.0520. Epub 2012 Aug 7.
引用本文的文献
1
Fasudil Enhances Therapeutic Efficacy of Neural Stem Cells in the Mouse Model of MPTP-Induced Parkinson's Disease.法舒地尔增强神经干细胞在 MPTP 诱导的帕金森病小鼠模型中的治疗效果。
Mol Neurobiol. 2017 Sep;54(7):5400-5413. doi: 10.1007/s12035-016-0027-8. Epub 2016 Sep 2.
本文引用的文献
1
Safety of traditional arab herbal medicine.传统阿拉伯草药的安全性。
Evid Based Complement Alternat Med. 2006 Dec;3(4):433-9. doi: 10.1093/ecam/nel058. Epub 2006 Sep 7.
2
Free radical scavenging and hepatoprotective activity of jigrine against galactosamine induced hepatopathy in rats.
J Ethnopharmacol. 2005 Mar 21;97(3):521-5. doi: 10.1016/j.jep.2004.12.016.
3
Pharmacodynamic basis for the use of chlorpromazine in psychiatry.
J Clin Exp Psychopathol. 1956 Jan-Mar;17(1):25-37.
4
Effects of folic acid and lamotrigine therapy in some rodent models of epilepsy and behaviour.
J Pharm Pharmacol. 2003 Mar;55(3):387-91. doi: 10.1211/002235702757.
5
Behavioural effects in rodents of methyl angolensate: a triterpenoid isolated from Entandrophragma angolense.安哥拉酸甲酯对啮齿动物的行为影响：一种从安哥拉楝中分离出的三萜类化合物。
Pharmacol Toxicol. 2002 Aug;91(2):71-6. doi: 10.1034/j.1600-0773.2002.910205.x.
6
Evaluation of hepatoprotective potential of jigrine post-treatment against thioacetamide induced hepatic damage.对叶百部治疗后对硫代乙酰胺诱导的肝损伤的肝保护潜力评估。
J Ethnopharmacol. 2002 Jan;79(1):35-41. doi: 10.1016/s0378-8741(01)00349-x.
7
Behavioral and pharmaco-toxicological study of Papaver rhoeas L. in mice.虞美人在小鼠中的行为学与药物毒理学研究。
J Ethnopharmacol. 2001 Mar 3;74(3):265-74. doi: 10.1016/s0378-8741(00)00383-4.
8
Protection from phenytoin-induced cognitive deficit by Bacopa monniera, a reputed Indian nootropic plant.
J Ethnopharmacol. 2000 Aug;71(3):383-90. doi: 10.1016/s0378-8741(99)00213-5.
9
Activity on the central nervous system of Himanthalia elongata; Part II.长囊水云对中枢神经系统的作用；第二部分
Planta Med. 1993 Apr;59(2):101-5. doi: 10.1055/s-2006-959622.
10
The 5-HT2 receptor antagonist ketanserine prevents electroconvulsive shock- and clonidine-induced amnesia.
Pharmacol Biochem Behav. 1994 Dec;49(4):849-52. doi: 10.1016/0091-3057(94)90233-x.
Zotero 插件