Bhat P S, Pardal P K, Das R C
Department of Psychiatry, AFMC, Pune, India.
Ind Psychiatry J. 2009 Jul;18(2):117-8. doi: 10.4103/0972-6748.62272.
After traumatic brain injury (TBI), the most disabling problems are generally related to neuropsychiatric sequelae, including personality change and cognitive impairment, rather than neurophysical sequelae. Kluver-Bucy syndrome (KBS) is a rare neurobehavioral condition, first described in 1937 as an experimental neurobehavioral syndrome in monkeys with bitemporal brain lesions. The syndrome in man was subsequently observed to be transient or permanent in a variety of neurodegenerative disorders and after traumatic, nontraumatic and infectious brain injury. However, partial KBS may occur in the absence of the classic bilateral temporal lesion, though rare. Pharmacological treatment of post-TBI neuropsychiatric sequelae consists of symptomatic, functional and hypothetical approaches. Specific pharmacological treatment consists of antipsychotics, anti-kindling anticonvulsants or a combination thereof. A case of partial KBS presenting as delayed manifestation of traumatic brain injury that improved with carbamazapine and antipsychotics is presented.
创伤性脑损伤（TBI）后，最致残的问题通常与神经精神后遗症有关，包括人格改变和认知障碍，而非神经物理后遗症。克吕弗-布西综合征（KBS）是一种罕见的神经行为疾病，1937年首次被描述为患有双侧颞叶脑损伤的猴子的实验性神经行为综合征。随后在人类中观察到该综合征在各种神经退行性疾病以及创伤性、非创伤性和感染性脑损伤后可呈短暂性或永久性。然而，部分KBS可能在无典型双侧颞叶病变的情况下出现，尽管较为罕见。TBI后神经精神后遗症的药物治疗包括对症、功能性和假设性方法。特异性药物治疗包括抗精神病药、抗点燃性抗惊厥药或两者联合使用。本文报告了1例以创伤性脑损伤延迟表现形式出现的部分KBS病例，该病例经卡马西平和抗精神病药治疗后病情改善。
