Kraychete Durval Campos, Sakata Rioko Kimiko, Issy Adriana Machado, Bacellar Olívia, Santos-Jesus Rogério, Carvalho Edgar Marcelino
Universidade Federal da Bahia, Salvador, Bahia, Brazil.
Sao Paulo Med J. 2010;128(5):259-62. doi: 10.1590/s1516-31802010000500003.
the role of immune response and proinflammatory cytokines in the pathogenesis of chronic pain has been of growing interest. In order to evaluate whether there is any association between disc herniation and elevated cytokine levels, we measured cytokine levels in patients with chronic low back pain and in healthy subjects.
analytical cross-sectional study at the Pain Clinic of Universidade Federal da Bahia (UFBA).
cytokine levels were measured using the enzyme-linked immunosorbent assay (ELISA) technique on 23 patients with low back pain (G1) and on 10 healthy subjects (G2).
the levels of tumor necrosis factor-alpha [TNF-alpha] (G1 = 5.6 ± 2.3 pg/ml; G2 = 1.6 ± 0.5 pg/ml; P = 0.01) and interleukin-6 [IL-6] (G1 = 4.1 ± 3.0 pg/ml; G2 = 0.9 ± 0.4 pg/ml; P = 0.01) were higher in G1. There were no statistically significant differences in relation to interleukin-1 [IL-1] (G1 = 0.5 ± 0.3 pg/ml; G2 = 0.5 ± 0.1 pg/ml; P = 1) or soluble tumor necrosis factor receptor [sTNF-R] (G1 = 572 pg/ml ± 36; G2 = 581 ± 50 pg/ml; P = 0.87).
The patients with chronic low back pain due to disc herniation presented higher levels of TNF-alpha and IL-6, but not of IL-1 or sTNF-R.
免疫反应和促炎细胞因子在慢性疼痛发病机制中的作用越来越受到关注。为了评估椎间盘突出与细胞因子水平升高之间是否存在关联，我们测量了慢性下腰痛患者和健康受试者的细胞因子水平。
在巴伊亚联邦大学（UFBA）疼痛诊所进行的分析性横断面研究。
采用酶联免疫吸附测定（ELISA）技术，对23例下腰痛患者（G1组）和10例健康受试者（G2组）的细胞因子水平进行测量。
G1组肿瘤坏死因子-α [TNF-α]水平（G1 = 5.6 ± 2.3 pg/ml；G2 = 1.6 ± 0.5 pg/ml；P = 0.01）和白细胞介素-6 [IL-6]水平（G1 = 4.1 ± 3.0 pg/ml；G2 = 0.9 ± 0.4 pg/ml；P = 0.01）较高。白细胞介素-1 [IL-1]（G1 = 0.5 ± 0.3 pg/ml；G2 = 0.5 ± 0.1 pg/ml；P = 1）或可溶性肿瘤坏死因子受体[sTNF-R]（G1 = 572 pg/ml ± 36；G2 = 581 ± 50 pg/ml；P = 0.87）无统计学显著差异。
因椎间盘突出导致慢性下腰痛的患者，其TNF-α和IL-6水平较高，但IL-1或sTNF-R水平不高。
