内源性脑啡肽不参与加巴喷丁的脑抗痛觉过敏作用。
Endogenous enkephalin does not contribute to the cerebral anti-hyperalgesic action of gabapentin.
机构信息
Department of Anesthesia, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100730, China.
出版信息
Sci China Life Sci. 2010 Dec;53(12):1428-32. doi: 10.1007/s11427-010-4092-3. Epub 2010 Dec 23.
The aim of this study was to investigate the role of endogenous enkephalin in the cerebral antihyperalgesic action of gabapentin. Neuropathic pain models and antihyperalgesic effect of gabapentin were confirmed by the presentation and changes of mechanical allodynia and thermal hyperalgesia of operated mouse hind paws. The results suggested that endogenous enkephalin may not be involved in the antihyperalgesic effect of gabapentin.
本研究旨在探讨内源性脑啡肽在加巴喷丁脑内抗痛觉过敏中的作用。通过手术鼠后爪机械性痛觉过敏和热痛觉过敏的表现和变化，证实了神经病理性疼痛模型和加巴喷丁的抗痛觉过敏作用。结果表明，内源性脑啡肽可能不参与加巴喷丁的抗痛觉过敏作用。
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