5-羟色胺在食管和胃底静脉曲张发展中的作用。
Role of serotonin in development of esophageal and gastric fundal varices.
机构信息
Clinic of Gastroenterology, Clinical Center of Serbia, Faculty of Medicine, University of Belgrade, Dr. Koste Todorovića Street, No 2, 11000 Belgrade, Republic of Serbia.
出版信息
World J Gastroenterol. 2010 Dec 28;16(48):6135-8. doi: 10.3748/wjg.v16.i48.6135.
AIM
to determine the effect of free serotonin concentrations in plasma on development of esophageal and gastric fundal varices.
METHODS
this prospective study included 33 patients with liver cirrhosis and 24 healthy controls. Ultrasonography and measurement of serotonin concentration in plasma were carried out in both groups of subjects. The upper fiber panendoscopy was performed only in patients with liver cirrhosis.
RESULTS
the mean plasma free serotonin levels were much higher in liver cirrhosis patients than in healthy controls (219.0 ± 24.2 nmol/L vs 65.4 ± 18.7 nmol/L, P < 0.0001). There was no significant correlation between serotonin concentration in plasma and the size of the esophageal varices according to Spearman coefficient of correlation (r(s) = -0.217, P > 0.05). However, the correlation of plasma serotonin concentration and gastric fundal varices was highly significant (r(s) = -0.601, P < 0.01).
CONCLUSION
free serotonin is significant in pathogenesis of portal hypertension especially in development of fundal varices, indicating the clinical value of serotonergic receptor blockers in these patients.
目的
确定血浆游离血清素浓度对食管和胃底静脉曲张发展的影响。
方法
这项前瞻性研究包括 33 例肝硬化患者和 24 名健康对照者。两组受试者均行超声检查和血浆血清素浓度测定。仅对肝硬化患者行上纤维内镜检查。
结果
肝硬化患者的平均血浆游离血清素水平明显高于健康对照组（219.0±24.2 nmol/L 比 65.4±18.7 nmol/L，P<0.0001）。根据斯皮尔曼相关系数（r(s)=-0.217，P>0.05），血浆中血清素浓度与食管静脉曲张的大小之间无显著相关性。然而，血浆血清素浓度与胃底静脉曲张的相关性具有高度显著性（r(s)=-0.601，P<0.01）。
结论
游离血清素在门静脉高压症的发病机制中具有重要意义，尤其是在胃底静脉曲张的发展中，提示 5-羟色胺能受体阻滞剂在这些患者中的临床价值。
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