Department of Biology-DBRI, McGill University, Montreal, QC, Canada.
FEBS Lett. 2011 Apr 6;585(7):967-72. doi: 10.1016/j.febslet.2010.12.015. Epub 2010 Dec 21.
AMPK is a protein kinase activated by various cellular stresses such as glucose deprivation, hypoxia or exercise. Despite having been studied for decades only a limited number of targets have been well described in tissues as varied as liver, muscle, and adipose tissue. Recent studies have shown that AMPK does not function in a similar manner, or through identical targets, in all cellular situations, posing challenges to some accepted paradigms describing AMPK function. A combination of genetic models and cell biological analysis of AMPK function in specific cell/developmental/environmental contexts will be required to accurately complement our understanding of the role(s) of AMPK in cancer, diabetes and other diseases.
AMPK 是一种蛋白激酶，可被多种细胞应激激活，如葡萄糖缺乏、缺氧或运动。尽管已经研究了几十年，但在肝脏、肌肉和脂肪组织等各种组织中，只有有限数量的靶标得到了很好的描述。最近的研究表明，AMPK 在所有细胞情况下的作用方式或通过相同的靶标都不相同，这对一些描述 AMPK 功能的公认模式提出了挑战。需要结合遗传模型和特定细胞/发育/环境背景下 AMPK 功能的细胞生物学分析，才能准确补充我们对 AMPK 在癌症、糖尿病和其他疾病中的作用的理解。
