Van Assche F A
U.Z. Gasthuisberg Verloskunde, Gynaecologie, Leuven.
Verh K Acad Geneeskd Belg. 1990;52(2):105-25; discussion 125-6.
During normal pregnancy vascular and hemodynamic changes are present. These alterations are due to a change in the balance between prostacyclin and thromboxane in favour of prostacyclin. In pregnancy induced hypertension the balance is in favour of thromboxane, explaining the absence of the vascular adaptation of pregnancy. Pharmacologic approach to restore the balance in favour of prostacyclin are promising.
在正常妊娠期间，会出现血管和血液动力学变化。这些改变是由于前列环素和血栓素之间的平衡发生变化，有利于前列环素。在妊娠高血压综合征中，平衡有利于血栓素，这解释了为何缺乏妊娠时的血管适应性变化。采用药理学方法恢复有利于前列环素的平衡很有前景。
