Department of Psychology, University of Bonn, Germany.
Biol Psychiatry. 2011 Mar 15;69(6):601-3. doi: 10.1016/j.biopsych.2010.10.026. Epub 2010 Dec 23.
Pharmacological studies indicate a functional interaction between the serotonergic and oxytocinergic system.
This study tested for an interaction of the prominent serotonin transporter polymorphism (SLC6A4) and an oxytocin receptor gene variation on individual differences in negative emotionality in healthy Caucasians (n = 750).
Participants carrying both the homozygous LL-variant of the serotonin transporter polymorphism and the TT variant of the single nucleotide polymorphism rs2268498 on the oxytocin receptor gene showed lowest scores on the personality dimensions Fear and Sadness of the Affective Neuroscience Personality Scales, as well as on an underlying factor Negative Emotionality.
The observed interaction effect provides converging evidence from human molecular genetics that serotonergic and oxytocinergic neurotransmission are entwined and play a crucial role for human personality with implications for affective disorders.
药理学研究表明，5-羟色胺能和催产素能系统之间存在功能相互作用。
本研究在健康的白种人（n = 750）中，检测了 5-羟色胺转运体基因（SLC6A4）的一个重要多态性和催产素受体基因变异的单核苷酸多态性 rs2268498 之间的相互作用，对个体的负性情绪差异的影响。
携带 5-羟色胺转运体多态性纯合子 LL 变体和催产素受体基因上的单核苷酸多态性 rs2268498 的 TT 变体的参与者，在情感神经科学人格量表的恐惧和悲伤维度上，以及在潜在的负性情绪因子上的得分最低。
观察到的相互作用效应提供了来自人类分子遗传学的一致性证据，表明 5-羟色胺能和催产素能神经传递相互交织，对人类个性起着至关重要的作用，并对情感障碍产生影响。
