Department of Radiodiagnosis, Sanjay Gandhi Postgraduate Institute of Medical Sciences, Raebareli Road, Lucknow, Uttar Pradesh 226 014, India.
J Clin Neurosci. 2011 Feb;18(2):193-6. doi: 10.1016/j.jocn.2010.05.033. Epub 2010 Dec 22.
This study aimed to demonstrate age-related and gender-related changes in diffusion tensor imaging (DTI) indices of deep grey matter (GM) nuclei of the normal human brain. DTI was performed on 142 subjects (age: 10-52 years). Regions of interest were placed on the caudate nucleus (CN), putamen, globus pallidus, frontal white matter (WM), occipital WM, anterior and posterior limb of internal capsule, genu of the corpus callosum and splenium in all participants. The quadratic regression model was used to describe age-related and gender-related changes in DTI indices for GM and WM. We observed increased fractional anisotropy (FA) values with age up to adulthood in GM, and a rise up to the third decade of life followed by a decrease in FA for WM. We observed higher FA values in males compared to females in CN and all WM regions. Decreased mean diffusivity with age was observed in GM and WM irrespective of gender. This normative data may be valuable in the diagnosis of neurodegenerative diseases.
本研究旨在展示正常人类大脑深部灰质（GM）核弥散张量成像（DTI）指标的年龄相关性和性别相关性变化。对 142 名受试者（年龄：10-52 岁）进行了 DTI 检查。在所有参与者中，在尾状核（CN）、壳核、苍白球、额叶白质（WM）、枕叶 WM、内囊前肢和后肢、胼胝体膝部和压部放置了感兴趣区。使用二次回归模型描述 GM 和 WM 的 DTI 指标的年龄相关性和性别相关性变化。我们观察到 GM 中的各向异性分数（FA）值随年龄增长至成年期增加，而 WM 的 FA 值在生命的第三个十年上升后下降。我们观察到 CN 和所有 WM 区域的男性 FA 值高于女性。无论性别如何，GM 和 WM 的平均弥散度都随年龄增长而降低。这些正常数据可能对神经退行性疾病的诊断有价值。
