新型结构元件存在于非蛋白水解梭菌 F 型毒素基因簇内。
Novel structural elements within the nonproteolytic clostridium botulinum type F toxin gene cluster.
机构信息
Infant Botulism Treatment and Prevention Program, California Department of Public Health, 850 Marina Bay Parkway, Room E361, Richmond, CA 94804, USA.
出版信息
Appl Environ Microbiol. 2011 Mar;77(5):1904-6. doi: 10.1128/AEM.02422-10. Epub 2010 Dec 23.
Abstract
We sequenced for the first time the complete neurotoxin gene cluster of a nonproteolytic Clostridium botulinum type F. The neurotoxin gene cluster contained a novel gene arrangement that, compared to other C. botulinum neurotoxin gene clusters, lacked the regulatory botR gene and contained an intergenic is element between its orfX2 and orfX3 genes.
摘要
我们首次对非蛋白水解梭状芽胞杆菌 F 型的完整神经毒素基因簇进行了测序。神经毒素基因簇包含一种新颖的基因排列，与其他肉毒梭菌神经毒素基因簇相比，该排列缺少调节基因 botR，并在其 orfX2 和 orfX3 基因之间包含一个基因间 is 元件。
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2
Genomics. Genome project standards in a new era of sequencing.基因组学。测序新时代的基因组计划标准。
Science. 2009 Oct 9;326(5950):236-7. doi: 10.1126/science.1180614.
3
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4
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