Tolstova N V, Kotov S V, Kotov A S
Zh Nevrol Psikhiatr Im S S Korsakova. 2010;110(10):8-13.
The study included 32 patients with idiopathic generalized epilepsy, 20 patients with cryptogenic focal epilepsy and 20 healthy controls. Cognitive functions were assessed using tests of long- and short-term verbal memory (auditory, visual and motor), attention and word fluency. Correlations between clinical features of the epileptic process and cognitive deficit were analyzed. Cognitive functions in patients with epilepsy were significantly lower compared to controls. Long-term auditory verbal memory and attention were significantly worse in patients with cryptogenic focal epilepsy compared to those with idiopathic generalized epilepsy. The cognitive dysfunction was correlated with seizure frequency, disease duration, lifetime number of seizures, in particular generalized tonic-clonic seizures.
该研究纳入了32例特发性全身性癫痫患者、20例隐源性局灶性癫痫患者和20名健康对照者。使用长期和短期言语记忆（听觉、视觉和运动）、注意力及词汇流畅性测试来评估认知功能。分析了癫痫发作过程的临床特征与认知缺陷之间的相关性。与对照组相比，癫痫患者的认知功能显著更低。与特发性全身性癫痫患者相比，隐源性局灶性癫痫患者的长期听觉言语记忆和注意力显著更差。认知功能障碍与癫痫发作频率、病程、终生癫痫发作次数，尤其是全身强直阵挛发作相关。
