Institute for Cardiovascular Regeneration, Center of Molecular Medicine, University of Frankfurt, Theodor-Stern-Kai 7, Frankfurt, Germany.
Basic Res Cardiol. 2011 Jan;106(1):5-11. doi: 10.1007/s00395-010-0139-7. Epub 2010 Dec 24.
MicroRNAs (miRs) are small non-coding RNAs, which control gene expression either by inducing mRNA degradation or by blocking translation, and play a crucial role in tissue homeostasis. In the cardiovascular system, miRs were shown to control cardiac hypertrophy, fibrosis and apoptosis, angiogenesis, and vessel remodeling. In addition, miRs regulate stem cell maintenance and some miRs induced cell fate decisions. This review summarizes the current insights into the control of stem cells and lineage commitment by miRs focusing specifically to the regulation of endothelial, smooth muscle, and cardiac lineage.
MicroRNAs (miRs) 是小的非编码 RNA，通过诱导 mRNA 降解或阻止翻译来控制基因表达，在组织稳态中发挥关键作用。在心血管系统中，miRs 被证明可以控制心脏肥大、纤维化和细胞凋亡、血管生成和血管重塑。此外，miRs 调节干细胞的维持，一些 miRs 诱导细胞命运决定。本综述总结了目前对 miRs 控制干细胞和谱系分化的认识，重点关注内皮细胞、平滑肌和心肌谱系的调节。
