Institute for Cardiovascular Regeneration, Center of Molecular Medicine, University of Frankfurt, Frankfurt, Germany.
Circ Res. 2012 Mar 30;110(7):1014-22. doi: 10.1161/CIRCRESAHA.111.243394.
Stem cells hold great promise for regenerative medicine and the treatment of cardiovascular diseases. The mechanisms regulating self-renewal, pluripotency, and differentiation are not fully understood. MicroRNAs (miRs) are small noncoding RNAs controlling gene expression, either by inducing mRNA degradation or by blocking mRNA translation. The expression of miRs was shown to regulate various aspects of stem cell functions, including the maintenance and induction of pluripotency for reprogramming. In addition, some miRs control cell fate decisions. This review summarizes the role of miRs in reprogramming and embryonic stem cell self-renewal, and specifically addresses the regulation of cardiovascular cell fate decisions by miRs.
干细胞在再生医学和心血管疾病治疗方面具有巨大的应用潜力。然而，调控干细胞自我更新、多能性和分化的机制尚未完全阐明。微小 RNA（miRs）是一类小的非编码 RNA，可以通过诱导 mRNA 降解或阻止 mRNA 翻译来调控基因表达。miRs 的表达被证明可以调控干细胞功能的各个方面，包括多能性的维持和重编程诱导。此外，一些 miRs 还可以控制细胞命运决定。本文综述了 miRs 在重编程和胚胎干细胞自我更新中的作用，并特别探讨了 miRs 对心血管细胞命运决定的调控作用。
