Bio-X Center, Key Laboratory for the Genetics of Developmental and Neuropsychiatric Disorders, Ministry of Education, Shanghai Jiao Tong University, The Central White Building, 1954 Huashan Road, Shanghai, 200030, People's Republic of China.
Behav Genet. 2011 Jul;41(4):557-64. doi: 10.1007/s10519-010-9426-1. Epub 2010 Dec 24.
YWHAE is a gene encoding 14-3-3epsilon, which is highly conserved across species, from bacteria to humans, and binds to phosphoserine/phosphothreonine motifs in a sequence-specific manner. YWHAE has been reported to be associated with schizophrenia in a study based on the Japanese population. Here, we conducted a genetic association analysis between common SNPs in the YWHAE gene and psychiatric diseases including schizophrenia, major depressive disorder and bipolar disorder in Han Chinese samples (1140 schizophrenia cases, 1140 major depressive disorder cases, 1140 bipolar disorder cases and 1140 normal controls). We studied 11 SNPs, seven of which had previously been reported as significant, in YWHAE. No association was found with schizophrenia, major depressive disorder or bipolar disorder. Considering the size of our sample sets (power > 90%), our results suggest that the YWHAE does not play a major role in schizophrenia, major depressive disorder or bipolar disorder in the Han Chinese population.
YWHAE 基因编码 14-3-3epsilon，该基因在从细菌到人类的各种物种中高度保守，并以序列特异性方式与磷酸丝氨酸/磷酸苏氨酸基序结合。有研究报道，YWHAE 基因与日本人群中的精神分裂症有关。在此，我们对汉族人群中的精神分裂症、重度抑郁症和双相情感障碍等精神疾病与 YWHAE 基因常见 SNP 之间进行了遗传关联分析（1140 例精神分裂症病例、1140 例重度抑郁症病例、1140 例双相情感障碍病例和 1140 例正常对照）。我们研究了 YWHAE 中的 11 个 SNP，其中 7 个 SNP 先前被报道为显著相关。我们未发现 YWHAE 与精神分裂症、重度抑郁症或双相情感障碍存在关联。考虑到我们样本集的大小（效能>90%），我们的结果表明，YWHAE 基因在汉族人群中对精神分裂症、重度抑郁症或双相情感障碍的作用不大。
