6-苄氨基-4-氧代-1,4-二氢-1,8-萘啶和 4-氧代-1,4-二氢喹啉作为 HIV 整合酶抑制剂。
6-Benzylamino 4-oxo-1,4-dihydro-1,8-naphthyridines and 4-oxo-1,4-dihydroquinolines as HIV integrase inhibitors.
机构信息
Department of Discovery Chemistry, Ardea Biosciences, Inc., 4939 Directors Place, San Diego, CA 92121, USA.
出版信息
Bioorg Med Chem Lett. 2011 Jan 15;21(2):760-3. doi: 10.1016/j.bmcl.2010.11.108. Epub 2010 Nov 30.
PMID:21185178
Abstract
SAR studies on the quinolone carboxylic acid class of HIV-1 integrase inhibitors focused on improving the metabolic stability and led to the discovery of 27 and 38.
摘要
SAR 研究集中在改善代谢稳定性上，这是一类 HIV-1 整合酶抑制剂的喹诺酮羧酸类，由此发现了 27 和 38。
Zotero 插件