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我们应该在什么时候筛查妊娠期糖尿病?

[When should we screen for gestational diabetes?].

作者信息

Guedj A-M

机构信息

Service maladies métaboliques et endocriniennes, Hôpital Caremeau, CHU Nîmes, Place Pr Debré, 30900 Nîmes, France.

出版信息

J Gynecol Obstet Biol Reprod (Paris). 2010 Dec;39(8 Suppl 2):S214-9. doi: 10.1016/S0368-2315(10)70048-X.

Abstract

AIM

Consider the arguments for screening outside the classical period of 24-28 SA.

MATERIALS AND METHODS

A literature search between 1990 and 2010 was performed using the Pubmed and Cochrane database. Foreign societies guidelines were also consulted.

RESULTS

Screening for gestational diabetes is recommended between 24 and 28 weeks of pregnancy, when glucose tolerance deteriorates. However, for patients with certain risk factors, the increasing prevalence of type 2 diabetes in women of childbearing age requires earlier screening. Fasting blood glucose should be measured at the first visit during pregnancy for these patients. The diagnostics threshold is the same as for patients who are not pregnant, i.e. blood glucose > 1.26 g/L. On the other hand, the interest of screening for gestational diabetes at the beginning of pregnancy in the case of certain risk factors is not supported by prospective studies. It is therefore not recommended to perform an OGTT in early pregnancy in order to diagnose gestational diabetes. The search for a gestational diabetes, regardless of screening policy recommended, has to be performed between 24 and 28 weeks gestational age. There are no reasons to consider a new search for gestational diabetes at later stages.

摘要

目的

思考在妊娠24 - 28周这一经典筛查期之外进行筛查的相关论据。

材料与方法

利用PubMed和Cochrane数据库对1990年至2010年期间的文献进行检索。同时查阅了国外学会的指南。

结果

建议在妊娠24至28周期间进行妊娠期糖尿病筛查,此时糖耐量会恶化。然而,对于具有某些风险因素的患者,育龄女性中2型糖尿病患病率的上升需要更早进行筛查。对于这些患者,应在孕期首次就诊时测量空腹血糖。诊断阈值与未怀孕患者相同,即血糖>1.26 g/L。另一方面,前瞻性研究并不支持在存在某些风险因素的情况下于妊娠早期筛查妊娠期糖尿病。因此,不建议在妊娠早期进行口服葡萄糖耐量试验(OGTT)以诊断妊娠期糖尿病。无论推荐何种筛查策略,妊娠期糖尿病的筛查均应在孕24至28周之间进行。没有理由在更晚阶段重新进行妊娠期糖尿病筛查。

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