Pierro Agostino, Nah Shireen A
Department of Paediatric Surgery, UCL Insitute of Child Health and Great Ormond Street Hospital for Children, London, United Kingdom.
Semin Pediatr Surg. 2011 Feb;20(1):50-3. doi: 10.1053/j.sempedsurg.2010.10.009.
Congenital hyperinsulinism of infancy (CHI) is characterized by inappropriate insulin secretion resulting in persistent hypoglycemia, which can lead to irreversible severe neurological damage in the infant. Many patients with CHI will respond to medical therapy, but surgery is necessary in those that do not. There are 2 main histologic subtypes, diffuse and focal, both of which may require different surgical strategies. Near-total pancreatectomy is the procedure of choice for diffuse CHI, whereas a localized resection is curative in focal CHI. Open surgery is the traditional approach to pancreatic resection. However, laparoscopy is increasingly used, particularly in localized resection for focal disease. We describe both methods of pancreatectomy.
婴儿先天性高胰岛素血症（CHI）的特征是胰岛素分泌不当导致持续性低血糖，这可能会导致婴儿不可逆转的严重神经损伤。许多CHI患者对药物治疗有反应，但对无反应者则需要进行手术。有两种主要的组织学亚型，即弥漫性和局灶性，两者可能需要不同的手术策略。近全胰切除术是弥漫性CHI的首选手术方法，而局部切除术可治愈局灶性CHI。开放手术是胰腺切除的传统方法。然而，腹腔镜手术的应用越来越多，尤其是在局灶性疾病的局部切除中。我们描述了两种胰腺切除方法。
