Ma Jin-ping, Chen Jian-hui, Cai Shi-rong, Chen Chuang-qi, Cui Ji, Wang Zhao, Wu Kai-ming, He Yu-long, Zhan Wen-hua
Department of Gastrointestinal and Pancreatic Surgery, Sun Yat-sen University, Guangzhou 510080, China.
Zhonghua Wei Chang Wai Ke Za Zhi. 2010 Dec;13(12):903-6.
To investigate the clinicopathological characteristics between mucinous gastric cancer (MGC) and poorly differentiated gastric cancer(PDGC) and factors associated with prognosis.
Medical records of 1016 consecutive patients with gastric cancer were retrospectively reviewed. Sixty-eight patients with MGC and 508 with PDGC were identified. Clinicopathologic characteristics and overall survival data were analyzed.
As compared to PDGC patients, patients with MGC were significantly older [(59.2±11.9) years vs. (54.1±13.2) years], had significantly more distant metastasis(36.8% vs. 23.8%), more peritoneal seeding(29.4% vs. 16.9%), and less radical resection(60.3% vs. 76.6%). There were no significant differences in 5-year survival rate between MGC and PDGC patients(29.4% vs. 35.5%). However, for tumors in the middle third of the stomach, the survival rate of MGC patients was lower than that of PDGC. Using a Cox proportional hazard ratio model, lymph node involvement and radical resection were independent prognostic factors for survival of MGC patients, while tumor invasion, lymph node involvement, and radical resection were associated with survival in patients with PDGC.
Although MGC and PDGC differ in age, frequencies of peritoneal seeding, distant metastasis, and rate of radical resection, overall survival is comparable.
探讨黏液性胃癌（MGC）与低分化胃癌（PDGC）的临床病理特征及与预后相关的因素。
回顾性分析1016例连续性胃癌患者的病历资料。确定68例MGC患者和508例PDGC患者。分析临床病理特征和总生存数据。
与PDGC患者相比，MGC患者年龄显著更大[（59.2±11.9）岁 vs.（54.1±13.2）岁]，远处转移显著更多（36.8% vs. 23.8%），腹膜种植更多（29.4% vs. 16.9%），根治性切除更少（60.3% vs. 76.6%）。MGC和PDGC患者的5年生存率无显著差异（29.4% vs. 35.5%）。然而，对于胃中1/3的肿瘤，MGC患者的生存率低于PDGC患者。使用Cox比例风险模型，淋巴结受累和根治性切除是MGC患者生存的独立预后因素，而肿瘤浸润、淋巴结受累和根治性切除与PDGC患者的生存相关。
虽然MGC和PDGC在年龄、腹膜种植频率、远处转移和根治性切除率方面存在差异，但总生存率相当。
