Zhang Yu-feng, Shi Hong, Chen Lu-biao, Xu Qi-huan
Department of Infectious Diseases, Third Affiliated Hospital of Sun Yat-sen University, Guangzhou 510630, China.
Zhonghua Shi Yan He Lin Chuang Bing Du Xue Za Zhi. 2010 Jun;24(3):215-7.
To assess the diagnostic value of FIB-4 in chronic hepatitis B (CHB) by comparing their results with histological features.
212 chronic hepatitis B patients underwent liver biopsy with a blood sample taken simultaneously. The serum level of ALT, AST, PLT were tested. These results together with age of the patients were put into the formula and final results of FIB-4 were computed. Three different endpoints were studied according to liver fibrosis stage, namely significant fibrosis (S2 to s4), extensive fibrosis (S3 to S4) and cirrhosis (S4). With liver biopsy as the gold standard, ROC curves were delineated for different endpoints. The area under the ROC curves reflected its diagnostic values.
The distribution of their fibrosis stage was as follows, S0:3 (1.4%); S1:49 (23.1%); S2:66 (31.1%); S3:50 (23.6%); S4:44 (20.8%). That means 160 patients (75.5%) had significant fibrosis (S2 to S4), 94 (44.3%) had extensive fibrosis (S3 to S4) and 44 (20.8%) had cirrhosis (S4). The AUCs of FIB-4 for significant fibrosis, extensive fibrosis and cirrhosis were 0.733 (95% CI: 0.660-0.806, P < 0.01), 0.746 (95% CI: 0.679-0.813, P < 0.01), 0.756 (95% CI: 0.687-0.825, P < 0.01) respectively.
The FIB-4 index is a simple, accurate and inexpensive methed to assess liver fibrosis in chronic hepatitis and may reduce the need for liver biopsy.
通过将FIB-4的结果与组织学特征进行比较，评估其在慢性乙型肝炎（CHB）中的诊断价值。
212例慢性乙型肝炎患者同时进行肝活检并采集血样。检测血清谷丙转氨酶（ALT）、谷草转氨酶（AST）、血小板计数（PLT）水平。将这些结果与患者年龄代入公式，计算FIB-4的最终结果。根据肝纤维化分期研究三个不同的终点，即显著纤维化（S2至S4）、广泛纤维化（S3至S4）和肝硬化（S4）。以肝活检为金标准，绘制不同终点的ROC曲线。ROC曲线下面积反映其诊断价值。
其纤维化分期分布如下，S0：3例（1.4%）；S1：49例（23.1%）；S2：66例（31.1%）；S3：50例（23.6%）；S4：44例（20.8%）。这意味着160例患者（75.5%）有显著纤维化（S2至S4），94例（44.3%）有广泛纤维化（S3至S4），44例（20.8%）有肝硬化（S4）。FIB-4对于显著纤维化、广泛纤维化和肝硬化的曲线下面积（AUC）分别为0.733（95%可信区间：0.660-0.806，P<0.01）、0.746（95%可信区间：0.679-0.813，P<0.01）、0.756（95%可信区间：0.687-0.825，P<0.01）。
FIB-4指数是评估慢性肝炎肝纤维化的一种简单、准确且廉价的方法，可能减少肝活检的必要性。
