[缺氧高碳酸血症对肺小动脉中COX-2 mRNA表达的影响]
[Effect of hypoxic hypercapnia on expression of COX-2 mRNA in pulmonary arterioles].
作者信息
Zeng Hai-Huan, Wang Liang-Xing, Chen Shao-Xian, Wang Ming-Shan, Fan Xiao-Fang
机构信息
Department of Respirology, First Hospital, Wenzhou Medical College, Wenzhou 325003, China.
出版信息
Zhongguo Ying Yong Sheng Li Xue Za Zhi. 2006 Feb;22(1):114-6.
AIM
To study the effect of chronic hypoxic hypercapnia on expression of COX-2 mRNA in pulmonary arterioles.
METHODS
SD rats were randomly divided into two groups: control group and hypoxic hypercapnic group. COX-2 mRNA was observed in pulmonary arterioles by the technique of in situ hybridization.
RESULTS
mPAP, weight ratio of right ventricle (RV) to left ventricle plus septum (LV + S) and COX-2 mRNA in pulmonary arterioles were much higher in rats of hypoxic hypercapnic group than those of control group. Light microscopy showed that vessel smooth muscle cell hypertrophy and vessel cavity straightness were found in hypoxic hypercapnic group.
CONCLUSION
Changes of expressions of COX-2 mRNA may regulate hypoxic hypercapnic pulmonary hypertension.
目的
研究慢性低氧高碳酸血症对肺小动脉中COX-2 mRNA表达的影响。
方法
将SD大鼠随机分为两组：对照组和低氧高碳酸血症组。采用原位杂交技术观察肺小动脉中的COX-2 mRNA。
结果
低氧高碳酸血症组大鼠的平均肺动脉压、右心室（RV）与左心室加室间隔（LV + S）的重量比以及肺小动脉中的COX-2 mRNA均明显高于对照组。光镜检查显示低氧高碳酸血症组存在血管平滑肌细胞肥大和血管腔变直。
结论
COX-2 mRNA表达的变化可能调节低氧高碳酸血症性肺动脉高压。
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