Ashton-Beaucage Dariel, Therrien Marc
Institut de recherche en immunologie et cancérologie, Département de pathologie et biologie cellulaire, Université de Montréal, CP 6128, succursale centre-ville, Montréal, Québec, H3C 3J7 Canada.
Med Sci (Paris). 2010 Dec;26(12):1067-73. doi: 10.1051/medsci/201026121067.
Cells respond to changes in their environment, to developmental cues and to pathogen aggression through the action of a complex network of proteins. These networks can be split into a multitude of signalling pathways that relay signals from the microenvironment to the cellular components involved in eliciting a specific response. Perturbations in these signalling processes are at the root of multiple pathologies, the most notable of these being cancer. The study of receptor tyrosine kinase (RTK) signalling led to the first description of a mechanism whereby an extracellular signal is transmitted to the nucleus to induce a transcriptional response. Genetic studies conducted in drosophila and nematodes have provided key elements to this puzzle. Here, we briefly discuss the poorly known contribution of these multicellular organisms to our understanding of what has become a prototype in cell signalling as well as to the more recent description of the complex network of regulators that is now known to govern RTK/RAS/ERK signalling.
细胞通过一个复杂的蛋白质网络的作用来响应其环境变化、发育线索和病原体侵袭。这些网络可分为众多信号通路，这些信号通路将信号从微环境传递到参与引发特定反应的细胞成分。这些信号传导过程中的扰动是多种病理状况的根源，其中最显著的就是癌症。对受体酪氨酸激酶（RTK）信号传导的研究首次描述了一种机制，即细胞外信号被传递到细胞核以诱导转录反应。在果蝇和线虫中进行的遗传学研究为这个谜题提供了关键要素。在这里，我们简要讨论这些多细胞生物对我们理解已成为细胞信号传导原型的内容以及对目前已知调控RTK/RAS/ERK信号传导的复杂调节网络的最新描述所做出的鲜为人知的贡献。
