载脂蛋白 C-I 异构体与冠状动脉疾病患者相关。
Isoforms of apolipoprotein C-I associated with individuals with coronary artery disease.
机构信息
Laboratory for Cardiovascular Chemistry, Department of Chemistry, Texas A&M University, College Station, TX 77843-3255, USA.
出版信息
Biochem Biophys Res Commun. 2011 Jan 28;404(4):1034-8. doi: 10.1016/j.bbrc.2010.12.105. Epub 2010 Dec 25.
Abstract
Apolipoprotein C-I (apoC-I) is a 6.6kDa serum protein associated with high density lipoproteins (HDL) and triglyceride-rich lipoproteins. In this study, apoC-I was examined in high density lipoprotein subfractions from individuals with and without coronary artery disease (CAD). New isoforms of apoC-I, were detected in the cohort of individuals with CAD using mass spectrometry while the expected apoC-I isoforms were absent. In addition, the apoC-I mass spectra for the CAD cohort had satellite peaks indicative of the involvement of oxidative processes. Further analysis of the mass spectra of the CAD and non-CAD cohorts suggest that the origin of these new isoforms may be due to genetic mutations that could compromise the function of apoC-I.
摘要
载脂蛋白 C-I（apoC-I）是一种 6.6kDa 的血清蛋白，与高密度脂蛋白（HDL）和富含甘油三酯的脂蛋白有关。在这项研究中，研究了患有和不患有冠状动脉疾病（CAD）的个体的高密度脂蛋白亚组分中的 apoC-I。使用质谱法在患有 CAD 的个体的队列中检测到 apoC-I 的新同工型，而预期的 apoC-I 同工型不存在。此外，CAD 队列的 apoC-I 质谱具有卫星峰，表明存在氧化过程的参与。对 CAD 和非 CAD 队列的质谱进一步分析表明，这些新同工型的起源可能是由于遗传突变，这可能会损害 apoC-I 的功能。
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