Okazaki Ryo
Third Department of Medicine, Teikyo University Chiba Medical Center.
Clin Calcium. 2011 Jan;21(1):94-8.
Sclerostin is a secreted protein from osteocytes that inhibits Wnt signaling. Wnt signalling plays important roles in osteoblastic differentiation hence bone formation. Therefore, inhibition of sclerostin promotes bone formation. A monoclonal antibody has been generated against sclerostin, which has been shown to stimulate bone formation and increase bone volume in rodents and primates. Preliminary data on human showed this antibody increases markers for bone formation. Clinical phase 2 study using this antibody in postmenopausal osteoporosis was initiated in 2009, of which results are anticipated.
硬化素是一种由骨细胞分泌的蛋白质，可抑制Wnt信号通路。Wnt信号通路在成骨细胞分化进而在骨形成过程中发挥重要作用。因此，抑制硬化素可促进骨形成。一种针对硬化素的单克隆抗体已被研制出来，在啮齿动物和灵长类动物中，该抗体已被证明可刺激骨形成并增加骨量。关于人类的初步数据表明，这种抗体可增加骨形成标志物。2009年启动了使用该抗体治疗绝经后骨质疏松症的2期临床研究，目前期待研究结果。
