Endocannabinoid Research Group, Institute of Biomolecular Chemistry, CNR, Pozzuoli, Italy.
Nat Neurosci. 2011 Jan;14(1):9-15. doi: 10.1038/nn.2720.
Studies of the endocannabinoid system in the CNS have been mostly focused on endocannabinoid receptors and inactivating mechanisms. Until recently, very little was known about the role of biosynthetic enzymes in endocannabinoid signaling. New data from the recent development of pharmacological and genetic tools for the study of these enzymes point to their fundamental role in determining where and when endocannabinoids function, and raise the possibility of new intriguing and previously unsuspected concepts in the general strategy of endocannabinoid signaling. However, even with these new tools, the cross-talk between anandamide and 2-arachidonoylglycerol biosynthesis makes it difficult to dissect one from the other, and data will need to be interpreted with this in mind.
中枢神经系统中环腺苷酸系统的研究主要集中在内源性大麻素受体和失活机制上。直到最近，人们对生物合成酶在内源性大麻素信号传递中的作用知之甚少。最近为研究这些酶而开发的药理学和遗传学工具提供了新的数据，这些数据表明这些酶在决定内源性大麻素的作用位置和时间方面起着至关重要的作用，并提出了在一般内源性大麻素信号传递策略中存在新的有趣的和以前未被怀疑的概念的可能性。然而，即使有了这些新工具，由于花生四烯酸乙醇胺和 2-花生四烯酰甘油生物合成之间的串扰，也很难将两者区分开来，因此需要考虑到这一点来解释数据。
