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鉴定出在大脑中介导大部分逆行信号的内源性大麻素的合成途径。

Identification of the synthetic pathway producing the endocannabinoid that mediates the bulk of retrograde signaling in the brain.

机构信息

Department of Neurobiology, Harvard Medical School, 220 Longwood Avenue, Boston, MA 02115, USA.

出版信息

Neuron. 2010 Feb 11;65(3):291-2. doi: 10.1016/j.neuron.2010.01.030.

DOI:10.1016/j.neuron.2010.01.030
PMID:20159441
Abstract

Endocannabinoids serve as retrograde messengers that are released by postsynaptic cells to regulate neurotransmitter release from presynaptic boutons. A new study in this issue of Neuron by Tanimura et al. establishes that most endocannabinoid signaling in the brain is a consequence of the calcium-dependent or receptor-driven generation of the retrograde signal 2-arachidonoylglycerol (2-AG) by diacylglycerol lipase alpha (DGLalpha).

摘要

内源性大麻素作为逆行信使，由突触后细胞释放，以调节从突触前末梢释放神经递质。在本期《神经元》杂志上，Tanimura 等人的一项新研究表明，大脑中大多数内源性大麻素信号是由二酰基甘油脂肪酶 α（DGLα）依赖性钙或受体驱动产生的逆行信号 2-花生四烯酸甘油（2-AG）的结果。

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