Liu Ting, Wang Xinyun, Zhu Congzhong, Li Yan, Sun Cuiyun, Wang Aixiang
Zhongguo Fei Ai Za Zhi. 2005 Apr 20;8(2):116-9. doi: 10.3779/j.issn.1009-3419.2005.02.09.
KAI1 is a new identified metastasis-suppressor gene whose expression in many types of tumors has been reported. The aim of study is to investigate the role of KAI1 protein in development of lung cancer and its values in predicting the prognosis of lung cancer.
The expressions of KAI1 protein were detected in benign pulmonary disease tissue, precancerous disease tissue, lung cancer tissue and metastatic lung cancer tissue in local lymph node using tissue microarray and immunohistochemical method. The relationship between expression of KAI1 protein and clinicopathological parameters of patients with lung cancer was analyzed by Chi-Square test and Fisher exact test.
The positive rate of KAI1 expression was 100.0% in 10 cases of benign pulmonary diseases, 66.7% in 12 cases of precancerous diseases, 24.7% in 89 cases of primary lung cancer and 0 in metastatic lung cancer tissue in local lymph node respectively. The KAI1 protein expression in primary lung cancer tissues had no remarkable relationship with age and gender of the patients and the location of cancer, but had significant relationship with the histological type and differentiated degree of tumor, P-TNM stages and lymph node metastatic status.
The abnormal expression of KAI1 protein may participate in malignant progression of lung cancer. Its downregulation may promote the invasion and metastasis of tumor cell. Detection of the expression of KAI1 protein may be helpful to predict the prognosis of lung cancer.
KAI1是一种新发现的转移抑制基因，已有报道称其在多种肿瘤类型中表达。本研究旨在探讨KAI1蛋白在肺癌发生发展中的作用及其在预测肺癌预后方面的价值。
采用组织芯片和免疫组化方法检测良性肺疾病组织、癌前疾病组织、肺癌组织及局部淋巴结转移癌组织中KAI1蛋白的表达。采用卡方检验和Fisher确切概率法分析KAI1蛋白表达与肺癌患者临床病理参数之间的关系。
10例良性肺疾病中KAI1表达阳性率为100.0%，12例癌前疾病中为66.7%，89例原发性肺癌中为24.7%，局部淋巴结转移癌组织中为0。原发性肺癌组织中KAI1蛋白表达与患者年龄、性别及肿瘤位置无明显关系，但与肿瘤组织学类型、分化程度、P-TNM分期及淋巴结转移状态有显著关系。
KAI1蛋白的异常表达可能参与肺癌的恶性进展。其表达下调可能促进肿瘤细胞的侵袭和转移。检测KAI1蛋白表达可能有助于预测肺癌的预后。
