Taziki Omolbanin, Espahbodi Fatemeh, Alizadeh Forutan Maryam, Kashi Zahra
Department of Nephrology, Imam Khomeini Hospital, Mazandaran University of Medical Sciences, Sari, Iran.
Iran J Kidney Dis. 2011 Jan;5(1):57-62.
INTRODUCTION. After kidney transplantation, patients appear to have vitamin D deficiency due to the use of immunosuppressive treatment and prevention of sunlight. This study was designed to determine vitamin D serum levels in kidney transplant patients in comparison with healthy individuals. MATERIALS AND METHODS. Forty-six kidney transplant patients with a creatinine clearance greater than 60 mL/min and 46 healthy individuals with normal kidney function were tested for serum levels of calcium, phosphorus, 25-hydroxyvitamin D, and parathyroid hormone at the end of the summer. RESULTS. Thirty-one participants were men and 15 were women in each group. The mean age was 41.0 ± 14.2 years in kidney transplant recipients and 41.4 ± 13.7 years in the control group. Inadequate serum 25-hydroxyvitamin D was seen in 93.5% of the transplant patients and in 89.1% of the controls. There was a 26.1% [corrected] vitamin D insufficiency (20 ng/mL to 30 ng/mL) and a 67.4% [corrected] deficiency (lower than 20 ng/mL) in the patients, and these rates were 21.7% [corrected] and 67.4% [corrected] in the control group, respectively. There was no significant difference between the two groups. CONCLUSIONS. Vitamin D deficiency is prevalent in kidney transplant patients. Lack of a significant difference between our two groups may be attributable to the high prevalence of vitamin D deficiency in general population and the use of vitamin D supplementation in transplant patients. Indeed, adequate doses of vitamin D in these patients are undetermined. They may need higher doses for normalization of serum vitamin D and metabolic requirements.
引言。肾移植后，由于使用免疫抑制治疗以及避免阳光照射，患者似乎会出现维生素D缺乏的情况。本研究旨在比较肾移植患者与健康个体的血清维生素D水平。材料与方法。在夏季末，对46名肌酐清除率大于60 mL/分钟的肾移植患者和46名肾功能正常的健康个体进行了血清钙、磷、25-羟维生素D和甲状旁腺激素水平的检测。结果。每组中31名参与者为男性，15名参与者为女性。肾移植受者的平均年龄为41.0±14.2岁，对照组的平均年龄为41.4±13.7岁。93.5%的移植患者和89.1%的对照组血清25-羟维生素D水平不足。患者中维生素D不足（20 ng/mL至30 ng/mL）的比例为26.1%[校正后]，缺乏（低于20 ng/mL）的比例为67.4%[校正后]，对照组中这两个比例分别为21.7%[校正后]和67.4%[校正后]。两组之间无显著差异。结论。维生素D缺乏在肾移植患者中普遍存在。两组之间缺乏显著差异可能归因于普通人群中维生素D缺乏的高患病率以及移植患者中维生素D补充剂的使用。实际上，这些患者中合适的维生素D剂量尚未确定。他们可能需要更高剂量的维生素D才能使血清维生素D水平正常化并满足代谢需求。
