高原缺氧环境下高血细胞比容与血液黏度变化关系的研究
[Study on the relationship of high hematocrit with changes of the blood viscosity during in the environment of altitude hypoxia].
作者信息
Cheng S K, Yu J Y, Si B H, Xiao Q L, Liang Z J
机构信息
Shanghai Provincial Corps Hospital, Chinese People's Armed Police Forces, Shanghai 201103, China.
出版信息
Zhongguo Ying Yong Sheng Li Xue Za Zhi. 2001 Aug;17(3):231-5.
AIM
To investigate the relationship of high hematocrit with changes of the blood viscosity during in the environment of altitude hypoxia.
METHODS
Index of hemorheology was determined from populations with different time of inhabit highland and normal controls.
RESULTS
(1) Hematocrit and RBC deformability were higher in all highland populations than that in normal controls, these increase were time-dependent. (2) The blood viscosity was increased significantly during the early stage of inhabit highland, and restored normal in late stage. (3) RBC aggregability was reduced significantly with time-dependent in highland populations. (4) The oxygen content of tissue was reduced significantly during the early stage of inhabit highland, and restored normal in late stage.
CONCLUSIONS
In the environment of altitude hypoxia, RBC deformability increase and RBC aggregability decrease can suppress blood viscosity increase induced by erythrocytosis, these compensatory regulation is help to maintain the normal oxygen content of tissue.
目的
探讨高原低氧环境下高血细胞比容与血液黏度变化的关系。
方法
测定不同高原居住时间人群及正常对照组的血液流变学指标。
结果
（1）所有高原人群的血细胞比容和红细胞变形性均高于正常对照组，且呈时间依赖性增加。（2）高原居住初期血液黏度显著升高，后期恢复正常。（3）高原人群红细胞聚集性随时间显著降低。（4）高原居住初期组织氧含量显著降低，后期恢复正常。
结论
在高原低氧环境下，红细胞变形性增加和红细胞聚集性降低可抑制红细胞增多症引起的血液黏度升高，这些代偿性调节有助于维持组织正常氧含量。
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