Kim Gi Beom
Department of Pediatrics, Seoul National University Children's Hospital, Seoul, Korea.
Korean J Pediatr. 2010 Jun;53(6):688-93. doi: 10.3345/kjp.2010.53.6.688. Epub 2010 Jun 23.
An increase in the number of preterm infants and a decrease in the gestational age at birth have resulted in an increase in the number of patients with significant bronchopulmonary dysplasia (BPD) and secondary pulmonary hypertension (PH). PH contributes significantly to the high morbidity and mortality in the BPD patients. Therefore, regular monitoring for PH by using echocardiography and B-type natriuretic peptide (BNP) or N-terminal-proBNP must be conducted in the BPD patients with greater than moderate degree to prevent PH and to ensure early treatment if PH is present. In the BPD patients with significant PH, multi-modality treatment, including treatment for correcting an underlying disease, oxygen supply, use of diverse selective pulmonary vasodilators (inhaled nitric oxide, inhaled prostacyclins, sildenafil, and endothelin-receptor antagonist) and other methods, is mandatory.
早产婴儿数量的增加以及出生时胎龄的降低，导致了严重支气管肺发育不良（BPD）和继发性肺动脉高压（PH）患者数量的增加。PH是导致BPD患者高发病率和高死亡率的重要因素。因此，对于中度以上的BPD患者，必须定期使用超声心动图和B型利钠肽（BNP）或N末端脑钠肽前体（NT-proBNP）监测PH，以预防PH，并确保在出现PH时能早期治疗。对于有严重PH的BPD患者，必须采取多模式治疗，包括治疗基础疾病、供氧、使用多种选择性肺血管扩张剂（吸入一氧化氮、吸入前列环素、西地那非和内皮素受体拮抗剂）及其他方法。
