Department of Neurosurgery, University Hospital, Grenoble, France.
J Neural Transm (Vienna). 2011 Jun;118(6):915-24. doi: 10.1007/s00702-010-0556-7. Epub 2010 Dec 29.
In advanced Parkinson's disease, several therapeutical option including not only lesional surgery (VIM, GPi) and deep brain stimulation (STN, GPi, VIM) but also continuous subcutaneous apomorphine infusion therapy can be proposed to the patient. The choice depends on the hope of the patient, patient's general health condition and the experience and choice of the neurosurgical and neurologist team. Here we report our experience based on 400 STN-DBS cases and we discuss, on the basis of our experience and on the literature, the advantage and disadvantage of DBS strategy as compared with non-surgical option such as continuous subcutaneous apomorphine infusion therapy.
在晚期帕金森病中，可以向患者提出多种治疗选择，不仅包括病灶手术（VIM、GPi）和深部脑刺激（STN、GPi、VIM），还包括持续皮下阿朴吗啡输注疗法。选择取决于患者的期望、患者的一般健康状况以及神经外科医生和神经科医生团队的经验和选择。在这里，我们报告了我们基于 400 例 STN-DBS 病例的经验，并根据我们的经验和文献讨论了 DBS 策略与非手术选择（如持续皮下阿朴吗啡输注疗法）相比的优缺点。
