近临界涨落和细胞骨架辅助的相分离导致细胞膜中的亚扩散。
Near-critical fluctuations and cytoskeleton-assisted phase separation lead to subdiffusion in cell membranes.
机构信息
Biophysics, BIOTEC, Technische Universität Dresden, Dresden, Germany.
出版信息
Biophys J. 2011 Jan 5;100(1):80-9. doi: 10.1016/j.bpj.2010.11.002.
Abstract
We address the relationship between membrane microheterogeneity and anomalous subdiffusion in cell membranes by carrying out Monte Carlo simulations of two-component lipid membranes. We find that near-critical fluctuations in the membrane lead to transient subdiffusion, while membrane-cytoskeleton interaction strongly affects phase separation, enhances subdiffusion, and eventually leads to hop diffusion of lipids. Thus, we present a minimum realistic model for membrane rafts showing the features of both microscopic phase separation and subdiffusion.
摘要
我们通过对双组份脂质膜进行蒙特卡罗模拟来研究细胞膜的微异质性与异常扩散之间的关系。我们发现，细胞膜中的近临界涨落会导致瞬时亚扩散，而细胞膜-细胞骨架相互作用则强烈影响相分离，增强亚扩散，并最终导致脂质的跳跃扩散。因此，我们提出了一个具有微观相分离和亚扩散特征的最小现实模型来展示膜筏的特征。
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