膜组织的奥秘：脂筏的组成、调控及作用
The mystery of membrane organization: composition, regulation and roles of lipid rafts.
作者信息
Sezgin Erdinc, Levental Ilya, Mayor Satyajit, Eggeling Christian
机构信息
MRC Human Immunology Unit, Weatherall Institute of Molecular Medicine, University of Oxford, Headley Way, Oxford OX3 9DS, UK.
Department of Integrative Biology and Pharmacology, University of Texas Health Science Center, 6431 Fannin Street, Houston, Texas 77030, USA.
出版信息
Nat Rev Mol Cell Biol. 2017 Jun;18(6):361-374. doi: 10.1038/nrm.2017.16. Epub 2017 Mar 30.
Abstract
Cellular plasma membranes are laterally heterogeneous, featuring a variety of distinct subcompartments that differ in their biophysical properties and composition. A large number of studies have focused on understanding the basis for this heterogeneity and its physiological relevance. The membrane raft hypothesis formalized a physicochemical principle for a subtype of such lateral membrane heterogeneity, in which the preferential associations between cholesterol and saturated lipids drive the formation of relatively packed (or ordered) membrane domains that selectively recruit certain lipids and proteins. Recent studies have yielded new insights into this mechanism and its relevance in vivo, owing primarily to the development of improved biochemical and biophysical technologies.
摘要
细胞膜在横向是异质的，具有多种不同的亚区室，它们在生物物理性质和组成上存在差异。大量研究集中于理解这种异质性的基础及其生理相关性。膜筏假说为这种横向膜异质性的一种亚型形式化了一种物理化学原理，其中胆固醇和饱和脂质之间的优先缔合驱动了相对紧密堆积（或有序）的膜结构域的形成，这些结构域选择性地募集某些脂质和蛋白质。最近的研究对这一机制及其在体内的相关性有了新的见解，这主要归功于改进的生化和生物物理技术的发展。
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