喹唑啉酮作为 γ-分泌酶调节剂。
Quinazolinones as γ-secretase modulators.
机构信息
Merck Research Laboratories Boston, 33 Avenue Louis Pasteur, Boston, MA 02115, USA.
出版信息
Bioorg Med Chem Lett. 2011 Jan 15;21(2):773-6. doi: 10.1016/j.bmcl.2010.11.111. Epub 2010 Nov 26.
PMID:21190851
Abstract
Synthesis, SAR and evaluation of styrenyl quinazolinones as novel gamma secretase modulators are presented in this communication. Starting from literature and in-house leads we evaluated a range of quinazolinones which showed good modulation of γ-secretase activity.
摘要
本通讯介绍了苯乙烯基喹唑啉酮作为新型γ-分泌酶调节剂的合成、SAR 和评价。从文献和内部先导化合物出发，我们评估了一系列喹唑啉酮，它们显示出对γ-分泌酶活性的良好调节作用。
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