Department of Analytical Chemistry, Faculty of Chemistry, University of Barcelona, Av. Diagonal 647, E-08028 Barcelona, Spain.
Rapid Commun Mass Spectrom. 2011 Jan 30;25(2):379-86. doi: 10.1002/rcm.4870.
We report a selective, sensitive and fast liquid chromatography/tandem mass spectrometry (LC/MS/MS) method for the determination of diallyldimethylammonium chloride (DADMAC) in water. Hydrophilic interaction liquid chromatography (HILIC) was used to avoid ion-pairing reagents, which are generally employed to retain cationic compounds. The complementary information obtained in a triple quadrupole mass spectrometer and in an ion trap Orbitrap has been used to study the fragmentation of the DADMAC cation M and for the correct assignment of the products ions. The HILIC/MS/MS method developed, using electrospray ionization in positive ion mode and selected reaction monitoring (SRM) acquisition mode, led to a reliable determination and confirmation of the DADMAC cation in water samples down to 50 ng L(-1). The low detection limit achieved, in combination with the absence of matrix effects, allowed the direct analysis of samples without any pretreatment, preconcentration or clean-up step. DADMAC was determined in samples collected in a drinking water treatment plant (DWTP) in Barcelona (Spain) and it was found in the influent at the µg L(-1) level.
我们报道了一种选择性、灵敏且快速的液相色谱/串联质谱（LC/MS/MS）方法，用于测定水中的二烯丙基二甲基氯化铵（DADMAC）。亲水作用色谱（HILIC）用于避免通常用于保留阳离子化合物的离子对试剂。三重四极杆质谱仪和轨道阱离子阱中获得的补充信息用于研究 DADMAC 阳离子[M]（+）的碎裂，并对产物离子进行正确的归属。开发的 HILIC/MS/MS 方法，采用正离子模式电喷雾电离和选择反应监测（SRM）采集模式，可在 50ng L（-1）以下可靠地测定和确证水中的 DADMAC 阳离子。实现的低检测限，结合无基质效应，允许直接分析未经任何预处理、预浓缩或净化步骤的样品。在西班牙巴塞罗那的饮用水处理厂（DWTP）采集的样品中测定了 DADMAC，并在进水口以μg L（-1）水平发现了它。
