Department of Obstetrics and Gynecology, The Ohio State University College of Medicine, Columbus, OH 43210-1267, USA.
J Low Genit Tract Dis. 2011 Jan;15(1):71-4. doi: 10.1097/LGT.0b013e3181e54061.
Graft-versus-host (GVH) disease is a common problem in transplant patients, whereas vulvovaginal gingival syndrome is an uncommon and severe variant of lichen planus characterized by erosions of characteristic mucosal surfaces, with frequent vaginal involvement, resulting in scarring or stricture formation. Both conditions have the potential to present with similar clinical pictures.
We report the history, evaluation, and treatment of a woman who had recently undergone stem cell transplant for acute lymphoblastic leukemia who presented with vaginal agglutination. A clinical diagnosis of erosive lichen planus versus chronic GVH disease was considered.
Lichen planus and GVH disease are both inflammatory processes, which can present with a range of clinical conditions. Each may result in the development of irritative symptoms and erosive lesions on mucosal surfaces. Although lichen planus is a well-defined dermatosis, GVH disease is an iatrogenic process. We report the case history of a patient with erosive vulvovaginal lesions with scarring, likely caused by GVH disease, which mimicked erosive vulvovaginal lichen planus. Although the clinical presentation and treatment of these 2 entities are similar, this case demonstrates the subtle diagnostic difference between the 2 diseases.
移植物抗宿主病（GVHD）是移植患者中常见的问题，而外阴阴道牙龈综合征是扁平苔藓的一种罕见且严重的变体，其特征为具有特征性黏膜表面的糜烂，常伴有阴道受累，导致瘢痕形成或狭窄。这两种情况都有可能出现类似的临床表现。
我们报告了一位最近因急性淋巴细胞白血病接受干细胞移植的女性的病史、评估和治疗情况，该女性出现阴道粘连。考虑了侵蚀性扁平苔藓与慢性 GVH 病的临床诊断。
扁平苔藓和 GVH 病都是炎症过程，可表现为一系列临床情况。两者都可能导致刺激性症状和黏膜表面的糜烂性病变。虽然扁平苔藓是一种明确的皮肤病，但 GVH 病是一种医源性疾病。我们报告了一名患有侵蚀性外阴阴道病变和瘢痕形成的患者的病史，可能由 GVH 病引起，其类似于侵蚀性外阴阴道扁平苔藓。尽管这两种实体的临床表现和治疗相似，但该病例表明了这两种疾病之间微妙的诊断差异。
