芳基腙酯的合成及其对白纹伊蚊产卵反应的生物评价。

Synthesis and bio-evaluation of aryl hydrazono esters for oviposition responses in Aedes albopictus.

机构信息

Defence R & D Establishment, Jhansi Road, Gwalior 474 002 (M.P.), India.

出版信息

Bioorg Med Chem Lett. 2011 Jan 15;21(2):794-7. doi: 10.1016/j.bmcl.2010.11.101. Epub 2010 Dec 4.

DOI:10.1016/j.bmcl.2010.11.101

PMID:21193312

Abstract

A novel series of aryl hydrazono esters (AHE) (1-13) were synthesized (yield 76-98%) to study the oviposition responses in Aedes albopictus (Skuse) mosquitoes for the first time. At a concentration of 10μgml(-1) in dual choice experiment, among the screened compounds, AHE-12 showed remarkable oviposition attractant activity with an oviposition activity index (OAI) of +0.299 (greater than 95% confidence limit) comparable to p-cresol (OAI +0.320) which is well-reported oviposition attractant for Aedes aegypti. Conversely, AHE-10 exhibited highest oviposition deterrent activity with OAI -0.247. The possible utilization of these compounds will be in integrated vector management strategies.

摘要

首次合成了一系列新型芳基腙酯（AHE）（1-13），以研究白纹伊蚊（Skuse）的产卵反应。在双选择实验中，浓度为 10μgml(-1)时，在所筛选的化合物中，AHE-12 表现出显著的产卵引诱活性，产卵活性指数（OAI）为+0.299（置信限大于 95%），可与 p-甲酚（OAI +0.320）相媲美，后者是一种广为报道的埃及伊蚊产卵引诱剂。相反，AHE-10 表现出最高的产卵驱避活性，OAI 为-0.247。这些化合物的可能用途将在于综合的病媒控制策略中。