FTO 与肥胖：缺失的一环。

FTO and obesity: the missing link.

机构信息

University of Cambridge Metabolic Research Laboratories, Institute of Metabolic Science, Addenbrooke's Hospital, Cambridge CB2 2QQ, UK.

出版信息

Cell Metab. 2011 Jan 5;13(1):7-8. doi: 10.1016/j.cmet.2010.12.016.

DOI:10.1016/j.cmet.2010.12.016

PMID:21195343

Abstract

Genome-wide association studies revealed that variants within FTO (fat-mass- and obesity-associated) are strongly associated with obesity susceptibility. A recent study in Nature Genetics (Church et al., 2010) demonstrates that mice overexpressing fto exhibit a dose-dependent increase in body weight, confirming a role for FTO in the development of obesity.

摘要

全基因组关联研究表明，FTO（脂肪量和肥胖相关）内的变异与肥胖易感性密切相关。《自然遗传学》（Nature Genetics）上的一项最新研究（Church 等人，2010）表明，过度表达 fto 的小鼠体重呈剂量依赖性增加，证实了 FTO 在肥胖发展中的作用。