Cancer Biology, Vanderbilt-Ingram Cancer Center, Vanderbilt University School of Medicine, Nashville, TN 37232, USA.
Front Biosci (Landmark Ed). 2011 Jan 1;16(1):105-15. doi: 10.2741/3678.
The serine-threonine kinase receptor-associated protein (STRAP) was initially identified as a putative inhibitor of the canonical TGF-beta signaling pathway. Because the Smad-dependent TGF-beta pathway negatively regulates cellular growth, early functional studies suggested that STRAP behaves as an oncogene. Indeed, a correlation between STRAP overexpression and various cancers has been identified. With the emergence of new studies on the biological function of STRAP, it is becoming clear that STRAP regulates several distinct cellular processes and modulates multiple signaling pathways. While STRAP itself does not possess enzymatic activity, it appears that STRAP influences biological processes through associations with cellular proteins. In this review, we will describe the TGF-beta-dependent and -independent functions of STRAP and provide a context for the significance of STRAP activity in the development of cancer.
丝氨酸-苏氨酸激酶受体相关蛋白（STRAP）最初被鉴定为经典 TGF-β信号通路的假定抑制剂。由于 Smad 依赖性 TGF-β通路负调控细胞生长，早期的功能研究表明 STRAP 作为一种癌基因发挥作用。事实上，已经发现 STRAP 过表达与各种癌症之间存在相关性。随着对 STRAP 生物学功能的新研究的出现，越来越清楚的是，STRAP 调节几种不同的细胞过程并调节多种信号通路。尽管 STRAP 本身不具有酶活性，但它似乎通过与细胞蛋白的关联来影响生物过程。在这篇综述中，我们将描述 STRAP 的 TGF-β依赖性和非依赖性功能，并为 STRAP 活性在癌症发展中的意义提供背景。
