Kang G H, Chi J G
Department of pathology, Seoul National University Children's Hospital, Korea.
J Korean Med Sci. 1990 Mar;5(1):59-64. doi: 10.3346/jkms.1990.5.1.59.
An autopsy case of congenital tuberculosis is described in a 41-day-old female infant who was born to a mother having active pulmonary tuberculosis. The primary complex was seen in the liver and portal lymph nodes, and there was a generalized miliary dissemination including lung, liver, spleen, pancreas, adrenals, thyroid, thymus, kidneys, brain, and bowel. The organism was confirmed to be Mycobacterium tuberculosis. The tubercles were histopathologically of various chronicity and characterized by massive caseation and fairly poor peripheral lymphohistiocytic reaction. Giant cell response was also minimal. It should be stressed that although rare, tuberculosis is still an important disease in Korea that can involve fetus or newborn infants if pregnant women are untreated or unnoticed for her tuberculosis.
本文描述了一例先天性结核病的尸检病例，患儿为一名41天大的女婴，其母亲患有活动性肺结核。在肝脏和肝门淋巴结中可见原发综合征，并且存在全身性粟粒性播散，累及肺、肝、脾、胰腺、肾上腺、甲状腺、胸腺、肾、脑和肠道。经证实，病原体为结核分枝杆菌。结核结节在组织病理学上具有不同的慢性程度，其特征为大量干酪样坏死，外周淋巴细胞组织细胞反应相当差。巨细胞反应也很轻微。应当强调的是，尽管罕见，但在韩国结核病仍然是一种重要疾病，如果孕妇的结核病未得到治疗或未被发现，该病可能累及胎儿或新生儿。
