Jiang Wen G, Ablin Richard J
Metastasis and Angiogenesis Research Group, Cardiff University School of Medicine, Cardiff, United Kingdom.
Front Biosci (Elite Ed). 2011 Jan 1;3(1):391-4. doi: 10.2741/e254.
The spread of cancer cells in the body -'metastasis,' is a challenging issue for cancer patients and for cancer research. From a clinical point of view, the majority of the cancer-related deaths in patients who suffer from solid cancers are metastasis-related. Although this life threatening consequence in cancer is recognised almost immediately at the time of diagnosis, the current-state-of-knowledge on the mechanisms and effective ways to combat cancer metastasis in clinical settings is far from being realized. Thus, making the necessity of continuing research into cancer metastasis evermore demanding and critical. This issue of the journal is directed toward consideration of some of the salient aspects of cancer metastasis, with a focus on recent progress of the molecular and cellular mechanisms of cancer invasion and metastasis.
癌细胞在体内的扩散——“转移”，对癌症患者和癌症研究来说都是一个具有挑战性的问题。从临床角度来看，实体癌患者中大多数与癌症相关的死亡都与转移有关。尽管在癌症诊断时几乎能立即认识到这种危及生命的后果，但目前对于临床环境中对抗癌症转移的机制和有效方法的了解还远远不够。因此，对癌症转移持续进行研究的必要性变得越来越迫切和关键。本期杂志旨在探讨癌症转移的一些显著方面，重点关注癌症侵袭和转移的分子及细胞机制的最新进展。
