Zamani Farhad, Fallahian Farahnaz, Hashemi Forough, Shamsaei Zeinab, Alavian Seyed-Moayed
Gastroenterintestinal and Liver Disease Research Center, Iran University of Medical Sciences, Tehran, Iran.
Saudi J Kidney Dis Transpl. 2011 Jan;22(1):179-84.
This study was performed to study the immune response to hepatitis B virus (HBV) vaccine in health-care workers. Through a cross-sectional study, relevant information and blood samples from 151 healthcare workers at the Firuzgar hospital were studied. The age range of the study individuals was 20-59 years, with the mean and standard deviation being 35.11 and 10.06, respectively. There were 24 males (15.9%) and 127 females (84.1%). The mean and median of months after HBV vaccination was 63.42 and 49.00, respectively. The mean and median of anti-HBs titer in those who received HBV vaccination was 164.81 and 200 milli international units per milliliter (mIU/mL), respectively. Of the 129 HBV-vaccinated subjects, 103 (68.2%) had anti-HBs titer >10 and 26 (17.2%) had anti-HBs titer <10. There was no association between gender and anti-HBs titer, but vaccination and adequate completion of its courses were associated with higher anti-HBs titer (P < 0.05). Also, the logistic regression method showed that the association between duration after vaccination and age with anti-HBs titer was not statistically significant. Our study suggests that the HBV vaccine immunization program had obtained excellent efficacy. There is need for further investigation among subjects who are not vaccinated against HBV but are positive for anti-HBs as well as in HBV-vaccinated subjects with low anti-HBs titers, about possible low-level viremia and other causes of lower vaccine efficacy, particularly in health-care workers.
本研究旨在探讨医护人员对乙型肝炎病毒（HBV）疫苗的免疫反应。通过横断面研究，对菲鲁兹加尔医院151名医护人员的相关信息和血液样本进行了研究。研究对象的年龄范围为20 - 59岁，平均年龄和标准差分别为35.11岁和10.06岁。其中男性24名（15.9%），女性127名（84.1%）。HBV疫苗接种后的平均月数和中位数分别为63.42个月和49.00个月。接种HBV疫苗者的抗-HBs滴度的平均值和中位数分别为每毫升164.81和200毫国际单位（mIU/mL）。在129名接种HBV疫苗的受试者中，103名（68.2%）的抗-HBs滴度>10，26名（17.2%）的抗-HBs滴度<10。性别与抗-HBs滴度之间无关联，但疫苗接种及其疗程的充分完成与较高的抗-HBs滴度相关（P < 0.05）。此外，逻辑回归方法显示，接种后持续时间和年龄与抗-HBs滴度之间的关联无统计学意义。我们的研究表明，HBV疫苗免疫计划取得了优异的效果。对于未接种HBV疫苗但抗-HBs呈阳性的受试者以及抗-HBs滴度较低的接种HBV疫苗的受试者，有必要进一步调查可能存在的低水平病毒血症以及疫苗效力较低的其他原因，特别是在医护人员中。
