Chauhan Sandeep, Malik Madhur, Malik Vishwas, Chauhan Yogender, Kiran Usha, Bisoi A K
Department of Cardiac Anesthesia, All India Institute of Medical Sciences, New Delhi, India.
Ann Card Anaesth. 2011 Jan-Apr;14(1):19-24. doi: 10.4103/0971-9784.74395.
Indications for extra corporeal membrane oxygenation (ECMO) after pediatric cardiac surgery have been increasing despite the absence of encouraging survival statistics. Modification of ECMO circuit led to the development of integrated ECMO cardiopulmonary bypass (CPB) circuit at the author's institute, for children undergoing repair of transposition of great arteries among other congenital heart diseases (CHD). In this report, they analyzed the outcome of children with CHD, undergoing surgical repair and administered ECMO support in the last 10 years. The outcome was analyzed with reference to the timing of intervention, use of integrated ECMO-CPB circuit, indication for ECMO support, duration of ECMO run and the underlying CHD. The results reveal a significantly improved survival rate with the use of integrated ECMO-CPB circuit and early time of intervention rather than using ECMO as a last resort in the management. The patients with reactive pulmonary artery hypertension respond favorably to ECMO support. In all scenarios, early intervention is the key to survival.
尽管小儿心脏手术后体外膜肺氧合(ECMO)的生存统计数据并不乐观,但其应用指征却在不断增加。在作者所在的机构,对体外膜肺氧合回路进行了改良,开发出了集成式体外膜肺氧合心肺转流(CPB)回路,用于患有大动脉转位及其他先天性心脏病(CHD)的儿童进行手术修复。在本报告中,他们分析了过去10年中接受手术修复并接受ECMO支持的先天性心脏病患儿的治疗结果。参考干预时机、集成式ECMO-CPB回路的使用情况、ECMO支持的指征、ECMO运行时间以及潜在的先天性心脏病对结果进行了分析。结果显示,使用集成式ECMO-CPB回路并尽早进行干预可显著提高生存率,而不是在治疗中将ECMO作为最后的手段。患有反应性肺动脉高压的患者对ECMO支持反应良好。在所有情况下,早期干预都是生存的关键。