Dyduch A, Steplewski Z, Koehler M, Piszka B
Pediatric Clinic, Silesian School of Medicine, Zabrze, Poland.
Pediatr Hematol Oncol. 1990;7(3):221-7. doi: 10.3109/08880019009033397.
Disaccharidases activity in the intestinal mucosa samples of rats was examined after intragastric and intramuscular methotrexate therapy. Methotrexate was given on a twice a week schedule (1 mg/kg body weight). The animals were sacrificed after 2 weeks, 1 month, and 2 months of this therapy. A statistically significant but transient decrease of the lactase and maltase activity was found. The authors suggest studying the beneficial effect of low disaccharidase diet in the first period of methotrexate therapy in children treated with methotrexate.
在大鼠经胃内和肌肉注射甲氨蝶呤治疗后，检测其肠黏膜样本中的双糖酶活性。甲氨蝶呤按每周两次的方案给药（1毫克/千克体重）。在该治疗2周、1个月和2个月后处死动物。发现乳糖酶和麦芽糖酶活性有统计学意义但短暂的下降。作者建议研究低双糖酶饮食在接受甲氨蝶呤治疗的儿童甲氨蝶呤治疗第一阶段的有益作用。
