Department of Chemistry, University of Illinois at Urbana-Champaign, Urbana, Illinois, USA.
Nat Chem Biol. 2011 Feb;7(2):78-80. doi: 10.1038/nchembio.509. Epub 2011 Jan 2.
Sublancin is shown to be an S-linked glycopeptide containing a glucose attached to a cysteine residue, establishing a new post-translational modification. The activity of the S-glycosyl transferase was reconstituted in vitro, and the enzyme is shown to have relaxed substrate specificity, allowing the preparation of analogs of sublancin. Glycosylation is essential for its antimicrobial activity.
Sublancin 被证明是一种 S 连接的糖肽，其中含有一个连接到半胱氨酸残基的葡萄糖，这建立了一种新的翻译后修饰。S-糖基转移酶的活性在体外得到了重建，并且该酶显示出放松的底物特异性，允许制备 sublancin 的类似物。糖基化对于其抗菌活性是必不可少的。
Zotero 插件