Center for Stem Cell Engineering, Department of Basic Research Laboratories, Texas Heart Institute, Houston, TX, USA.
Wiley Interdiscip Rev Syst Biol Med. 2011 Jul-Aug;3(4):446-57. doi: 10.1002/wsbm.130. Epub 2010 Dec 31.
Small ubiquitin-related modifiers, or SUMOs, have emerged as versatile regulators of many biological functions that do so by covalent attachment to a variety of substrates via enzymatic reactions. SUMO conjugation has also been shown to be involved in a number of human pathogenic processes. More recent advances in the SUMO field have indicated a potential role for SUMO conjugation pathway in cardiogenesis. This advanced review will describe the basic features of the SUMO conjugation pathway and will summarize the most recent studies implicating the influence of the sumoylation pathway in cardiac function under both physiological and pathological conditions. WIREs Syst Biol Med 2011 3 446-457 DOI: 10.1002/wsbm.130
小泛素相关修饰物(SUMO)通过酶促反应将其共价连接到各种底物上来调节多种生物学功能,现已成为多功能调节剂。SUMO 缀合也被证明参与了许多人类致病过程。SUMO 领域的最新进展表明 SUMO 缀合途径在心脏发生中可能具有作用。这篇高级综述将描述 SUMO 缀合途径的基本特征,并总结最近的研究,这些研究表明 SUMO 化途径在生理和病理条件下对心脏功能的影响。WIREs Syst Biol Med 2011 3 446-457 DOI:10.1002/wsbm.130