Suwannarurk Komsun, Bhamarapravatana Kornkarn, Kheolamai Pakpoom, Thaweekul Yuttadej, Mairaing Karicha, Poomtavorn Yenrudee, Pattaraarchachai Junya
Gynecologic Oncology Unit, Department of Obstetrics and Gynecology, Faculty of Medicine, Thammasat University, Pathumthani, Thailand.
Asian Pac J Cancer Prev. 2010;11(5):1397-401.
To study the accuracy of self vaginal douching and collection for HPV types 16, 18, 31 and 33 in women visiting Thammasat Hospital for the explicit purpose of cervical screening.
A pelvic examination and Pap smear were performed for all women who came for cervical screening. Specimens were also collected by self vaginal douching before cervical screening and sent to the cell and molecular biology laboratory for analysis of human papillomavirus (HPV) types 16, 18, 31 and 33 using the polymerase chain reaction (PCR).
HPV prevalence was 3.6% overall from 250 women in this study. Twenty-four (9.6%) women had an abnormal cytology screening result. No cancer was found. Four women had a high grade squamous intraepithelial lesion (HSIL) and 14 had a low grade squamous intraepithelial lesion (LSIL) from colposcopic biopsy. Self vaginal douching for HPV 16, 18, 31 and 33 was used to predict abnormal Pap smear. Sensitivity, specificity, positive predictive value (PPV) and negative predictive value (NPV) were 12.5%, 97.5%, 33.3% and 91.3%, respectively.
From our analysis of self-vaginal douching for HPV detection using cases from Thammasat university hospital, it cannot replace the Pap smear.
研究在泰国法政大学医院专为宫颈筛查而来就诊的女性中，自行阴道冲洗及采集样本检测16、18、31和33型人乳头瘤病毒（HPV）的准确性。
对所有前来进行宫颈筛查的女性进行盆腔检查和巴氏涂片检查。在宫颈筛查前，还通过自行阴道冲洗收集样本，并送至细胞与分子生物学实验室，采用聚合酶链反应（PCR）分析16、18、31和33型人乳头瘤病毒（HPV）。
本研究中250名女性的HPV总体患病率为3.6%。24名（9.6%）女性的细胞学筛查结果异常。未发现癌症。经阴道镜活检，4名女性有高级别鳞状上皮内病变（HSIL），14名有低级别鳞状上皮内病变（LSIL）。采用自行阴道冲洗检测HPV 16、18、31和33型来预测巴氏涂片异常。敏感性、特异性、阳性预测值（PPV）和阴性预测值（NPV）分别为12.5%、97.5%、33.3%和91.3%。
通过对泰国法政大学医院病例中采用自行阴道冲洗检测HPV的分析，我们发现它不能替代巴氏涂片检查。
